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Based on these studies, it appears that nicotine concentration of the e-liquid used is a major determinant of e-cigarette puffing topography (Cunningham et al., 2016

Vaping devices work by heating a liquid solution, often containing nicotine, that generates an inhaled aerosol, or vapor

This spark is even hotter than the flame itself and is capable of leaving a visible mark on metal surfaces

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Such advanced models are being utilized in preclinical safety profiling of therapeutics 25 and can be even combined with advanced aerosol inhalation systems 26 for toxicology and risk assessment studies

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