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Nicotine has been considered to prevent the risk of Parkinsons disease, playing a critical role in the regulation of striatal activity mediated by the dopaminergic system 35

Finally, apart from coronary arteries, smoking and OSAHS seem to also insult the myocardium, since, in patients with systolic heart failure, they predispose to nocturnal ventricular arrythmias, that might be proved fatal [122]

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The warnings and often gruesome, full-colour images of the consequences of smoking, such as mouth cancer and gangrenous toes, would cover 75 per cent of the packs' front