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Moreover, despite differences in pathophysiology and clinical outcome, the treatment of SAM has remained largely unchanged and is the same regardless of form 20,21,22

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13 Future savings provided by ACI could include avoiding multiple debridement and microfracture procedures on the same cartilage lesion and the need for a total joint replacement early in life and a subsequent revision TKA

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Additionally, individuals are encouraged to abstain from sexual activity for at least seven days after treatment to minimize the risk of spreading the infection

[21] [22] Studies of progeroid (premature aging) syndromes, which mimic the clinical and molecular characteristics of aging, have provided some insight into the mechanism of action of NAD+ replenishment