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The cell line was grown and maintained by culturing with feeder cells (SL10, Reprocell Inc.) at 37 C in 5% CO 2 in a humidified atmosphere, using Primate ES cell medium (Reprocell Inc.), supplemented with bFGF (Fujifilm Wako Pure Chemical Corporation)

Self-directed supplementation without medical oversight may complicate diabetes management or obscure the assessment of tirzepatide's therapeutic effects