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Description

Annu Rev Cell Dev Biol 14:117 Sikiric P, Petek M, Rucman R et al (1993) A new gastric juice peptide, BPC

Joyani Das

Once in the nucleus, it binds to specific transcription factors and DNA elements particularly antioxidant response elements (ARE) that are regulated by the stress-responsive factor NRF2. Through this mechanism, MOTS-c can turn on a suite of stress-defense and metabolic genes that help cells adapt to high-fat stress or insulin resistance