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The Marlboro Man was scrapped in the late Nighties, when state governments banned the use of humans or cartoons in U.S

Our results indicate that excessive use of cigarettes, or chronic exposure to their compounds, affects visual discrimination, supporting the existence of overall deficits in visual processing with tobacco addiction. Although the research did not give a physiological explanation for the results, Silverstein said that since nicotine and smoking harm the vascular system, the study suggests they also damage blood vessels and neurons in the retina

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In vivo versus in vitro airway surface liquid nicotine levels following cigarette smoke exposure