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Under these conditions, NOS activity becomes uncoupled resulting in the production of the superoxide radical and ONOO [48], toxic reactive compounds that rapidly oxidize BH4 favoring the establishment of oxidative stress [105,106] (Figure 2b)

The association between corticosteroid use and development of fractures among IBD patients in a population-based database

In theory, this results in stimulation of auditory circuits that are not involved in tinnitus and inhibition of the hyperactivated neurons causing tinnitus

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Consequently, an inhibitor of ATR blocks the replication of SARS-CoV-2 after entering cells and thus, was identified as a potential anti-COVID drug that exhibits antiviral activity against SARS-CoV-2 in diverse cell types (298)