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To establish more rigorous scientific evidence, a randomized, double-blind, placebo-controlled study was published in the journal Dermatology and Therapy in 2014

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In contrast, the genetic contribution to IBD in elderly patients is significantly reduced, with immunosenescence, dysbiosis, and comorbidities becoming predominant

An overflow of glutamate (the main endogenous excitatory amino in brain, at concentration of 515 mmol glutamate per kg body weight, higher than of any other neurotransmitter) is implicated in major psychiatric illnesses [1, 24,25,26]