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Extracellular matrix (ECM) remodeling is both a key hallmark of aging and a shared effector pathway

It has a high affinity for hepatocyte growth factor (HGF) with a Kd value of 65pM and enhances its activity on the receptor c-Met

Hendrickse P, Degens H

Its pharmacological activities encompass scavenging reactive oxygen species, mitigating toxic protein aggregation and cytotoxicity, repairing mitochondrial dysfunction, and inhibiting excessive neuronal apoptosis

[11] Notably, clinical studies to date have not identified any severe or lasting adverse events attributable to NAD+ Injection

10.1152/ajpheart.01323.2008 Am