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A study of 31 men in 2018 found that taking ibuprofen (Aleve/Motrin) at a dose of 600mg twice a day showed alterations in their testicular-pituitary axis function resulting in hypogonadism (low testosterone), though the direct impact on semen parameters was not evaluated

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Monitor any side effects, such as mild soreness at the injection site

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The main side effects men should anticipate are nausea (especially initially), possible flushing, and maybe a headache or mild dizziness