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What specific benefits have preclinical studies observed for each compound in models of metabolic disease

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Although many animals are able to cope and recover from a negative energy balance by metabolising body fat albeit with a negative impact on productivity at the sub-clinical stage, some metabolise too much fat, become overwhelmed with the associated by-products (ketone bodies), and develop pregnancy toxaemia (before kidding) and ketosis (after kidding)

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By modulating NNMT, 5-Amino-1MQ may enhance NAD availability , promote lean body composition , and support healthy aging and mitochondrial function