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Fortified tortillas made from masa produced through the traditional nixtamalization and wet-milling process, where folic acid was added to nixtamal before milling, contained 15%, 33%, and, in one study, even 80% less folic acid compared to the folic acid amount added to nixtamal (theoretical fortified level)

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For instance, certain strains of Gram-negative Enterobacteriaceae , which are present in larger quantities in patients with PD, such as Escherichia coli and Salmonella , were found to secrete pro-inflammatory lipopolysaccharides (LPS), which are associated with more severe motor symptoms [134]