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NR1D2-mediated PNPLA2/ATGL inhibition disrupts the lipid metabolism of macrophages in the human body, leading to lipid accumulation and weakening the effect of autophagy on Burkholderia pseudomallei immunity to infection, leading to the continued development of infection (Tang et al., 2021)

Its safety and efficacy for those uses are not fully evaluated by the FDA

42 In most tissues, the leukocyte recruitment follows a well-characterized cascade of sequential steps, including tethering, rolling, firm adhesion, intravascular crawling, and transendothelial migration

Ajithkumar T, Parkinson C, Fife K, Corrie P, Jefferies S (2015) Evolving treatment options for melanoma brain metastases

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