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These variants equally preserved their GSH-transferase activity, suggesting the importance of additional factors in the modulation of the negative log of GSHs acid dissociation constant (p K a ), including the ability to optimally arrange the well-described electron-sharing network which generates a positively charged electrostatic field in the G-site of GSTs 40,41

Navrot N, Collin V, Gualberto J, Gelhaye E, Hirasawa M, Rey P, Knaff DB, Issakidis E, Jacquot JP, Rouhier N (2006) Plant glutathione peroxidases are functional peroxiredoxins distributed in several subcellular compartments and regulated during biotic and abiotic stresses

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& Perlmutter, D

Vitamin C and Vitamin E also play important roles in glutathione metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] [26].Ilback NG, Fohlman J, Friman G, Effects of selenium supplementation on virus-induced inflammatory heart disease