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Laird NM, Ware JH

GPX4, using GSH as a cofactor, reduces cytotoxic lipid hydroperoxides (L-OOH) to benign lipid alcohols (L-OH) ( - transporter (a heterodimer of SLC7A11 and SLC3A2) ( 2 ), a potent lipophilic antioxidant that halts lipid peroxidation chain reactions ( Figure 2 )

doi: 10.1016/j.bbalip.2021.159110 144

These proteins interact to assemble an atypical heterodimeric E3 ubiquitin ligase complex with CUL1 and CUL5, which catalyzes the ubiquitination and degradation of JAK3