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However, from the very few biohackers who have put their lives on the line to experiment with this peptide, heres what has been reported so far Burning/itching at site of injection (here, here, and here) Fatigue Nausea Muscle soreness Vital biomarkers must be consistently tracked to gauge effectiveness of FOXO4-DRI (blood and urine tests, DNA methylation tests, medical scans, etc.) Longecity user Vantika advises to NOT take FOXO4-DRI with compounds such as Rapamycin, Quercetin, corticosteroids and cortisol to avoid diminishing its senolytic effects (a 1-2 week washout is what they recommend, possibly five weeks, and nothing shorter than 96 hours) FOXO4-DRI is likely useless for healthy men/women in their 20s/30s (as backed up by Longecity member Rocket here and here) The senolytic ability observed for FOXO4-DRI may prove to be too powerful in humans and have unintended consequences There is also a great deal of suspicion behind the testimonials of biohacker Darren Moore on top of taking multiple supplements simultaneously, he has allegedly failed to show independent proof he is taking 100% pure FOXO4-DRI