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NNMT inhibition follows dose-dependent curves: 50mg produces 4050% enzyme inhibition, 100mg achieves 6075%, with diminishing returns beyond 150mg

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Nature 528 , 267271 (2015)

Metabolism and excretion of the Once-Daily human Glucagon-Like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase