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6.2 Linking GSH/GSSG to Transcriptomic and Proteomic Regulation Transcriptomic and proteomic data can connect metabolite changes to functional modules: GCLC/GCLM/GSS for synthesis, SLC7A11 for substrate acquisition, GSR/GPX/GST for regeneration and use, pentose phosphate pathway enzymes for NADPH supply, and NRF2-KEAP1 signaling for coordinated antioxidant adaptation

In kidney transplantation, it was found that patients with chronic AMR have up-regulated immunoproteasome activity (109)

Without GSH depletion, exposure to both AQ-QI and DEAQ-QI increased caspase 3 activity by 60%

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Addition of a large quantity of the enzyme would have increased the enzymatic contribution of the total rate of reaction mixture but that would have made the rate too fast to measure accurately and conveniently, especially at high MBB concentration

10.1016/j.ijbiomac.2023.126300 170 ZhangJ.ChenQ.DuD.WuT.WenJ.WuM.et al (2019)