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Description

Nuclear-translocated Nrf2 directly downregulates BACE1 and its antisense RNA (BACE1-AS), suppressing A generation

It does this by working on several hormonal paths at the same time

Benefits

For instance, in SCD, the absence of spectrin ubiquitination produces excessively stable cytoskeletal complexes contributing to the characteristic rigidity of irreversibly sickled cells (Chang et al., 2005)