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doi: 10.1371/journal.pgen.1008396 34 PinheiroK

(Ohno S, Nakajin S, Drug MetabDispos, 37: 32-40, 2009), though mRNA and protein expression are not always well correlated, especially when comparing isoforms

Individuals with insulin resistance, elevated inflammation, or dysregulated adipose tissue may have blunted beta-3 receptor signaling that limits the peptides effectiveness