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However, other models (such as viral hepatitis) not summarized in this paper should be treated with caution

It will depend on the ability to connect multiple sources of evidence, including: Clinical trial data Real-world clinical data Patient-reported outcomes Biomarker and genomic information Healthcare utilization data Digital health technologies The goal is not to replace randomized clinical trials but to complement them, creating a more complete picture of how therapies perform in real-world healthcare settings

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Regular/moderate exercise has been shown to enhance antioxidant defense by incrementing the activity of endogenous antioxidant enzymes such as superoxide dismutase (SOD), GPx, and catalase (Miyata et al., 2008)