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Thus, different studies have also suggested the adverse impact of COVID-19 on male reproductive functions, mainly emphasizing on high expressions of angiotensin-converting enzyme 2 (ACE2) in the testes that allows the viral entry into the cells

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In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]

doi: 10.3389/fpls.2015.00754 Received 17 June 2015 Accepted 03 September 2015 Published 23 September 2015 Volume 6 - 2015 Edited by Raul Antonio Sperotto, Centro Universitrio UNIVATES, Brazil Reviewed by Bahar Yildiz Kutman, University of California, Davis, USA

The circulating level of IGF1 coupled with IGFBPs has been correlated with the risk of developing various cancers, including breast, lung, colon, and prostate cancers through human epidemiological studies (Hankinson et al., 1998

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