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Several pathologies that affect the brain and kidneys have been associated with dysbiosis of the gut microbiota, and compared to the general population, individuals with CKD have a higher propensity for cognitive impairment (Drew et al., 2019)

Where direct clinical evidence is limited, mechanistic findings are interpreted as hypothesis-generating rather than causal, in order to avoid overextension of preclinical results

5.5.2 Cyclodextrin (CD) CD is a water-soluble, biodegradable cyclic oligosaccharide that produces a mixture of -CD, -CD, and -CD composed of 6, 7, and 8 glucopyranose units, respectively

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Nevertheless, various stimuli such as chronic disease states, metabolic conditions (e.g., type 2 diabetes mellitus [T2DM], obesity, dyslipidemia), smoking, and disturbed blood flow can disrupt such a quiescent phenotype and lead to endothelial cell dysfunction (ECD) (Fig

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