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These effects were mediated through downstream activation of transcription factors including c-Fos, c-Jun, and EGR-1, which regulate genes involved in cell cycle progression, extracellular matrix remodelling, and angiogenic signalling

Human TSHR, encoded by the TSHR gene consisting of 10 exons on chromosome 14q31, is a G-protein-coupled receptor (GPCR) with one extracellular domain (ECD), seven transmembrane domains (TMDs), three extracellular loops (ECLs), three intracellular loops (ICLs), and one intracellular carboxy terminal (Fig

IHC staining The ECM of the human fetal kidney was analyzed using elastin, laminin, fibronectin, and collagens I and IV specific antigens for further IHC staining to verify the retention of major ECM components

Wang, and J

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