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There were also many studies in rats, and a few in mice, that showed the increased presence of ROS or activation of biomarkers of cellular responses to ROS, such as increased expression or activity of catalase, superoxide dismutase, or glutathione transferases in several tissues, including the liver, blood, spleen, kidney, and brain

Statistical analysis was performed using the two-sided Gehan-Breslow-Wilcoxon test

doi: 10.1016/j.neuroimage.2019.02.023, 47 HenningA.SchrM.SchulteR

Another study revealed that the oral administration of Polygonum cuspidatum aqueous extract in rats with resected exorbital lacrimal glands restored tear volume and Mucin4 (MUC4) expression by mitigating corneal abnormality and the release of inflammatory cytokines [76]

This could represent a novel pathogenic mechanism of particular relevance, especially for acromegaly, and underlines an exosome-mediated communication between GH-secreting pituitary adenomas and both osteoblast proliferation and bone formation

Zhang Y, and Zhang Z (2020) The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications Cell Mol Immunol 17 (8) 807821 PMID: 32612154 PMCID: 7395159 4