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Pancreatic cancer: Advances and challenges

Redox modifier genes and pathways in amyotrophic lateral sclerosis

Targeted gene deletions in mouse models highlight their unique functions - leptin knockouts develop severe obesity with decreased energy expenditure, while mice lacking adiponectin exhibit profound insulin resistance

Moreover, modulation of key inflammatory pathways and cell signaling cascades suggests that PYC may help mitigate virus-induced immunopathology, suppress tumor cell proliferation, induce apoptosis, and inhibit angiogenesis

Bansal A, Simon MC

Therapeutic targeting of AT ER stress shows promise through chemical chaperone interventions