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Cytochrome p450 oxidoreductase (POR) affects iron metabolism by removing hydrogen from polyunsaturated fatty acids, or by reducing Fe 3+ to Fe 2+ for electron transfer, to accelerate the circulation between Fe 3+ and Fe 2+ to promote ferroptosis (Zou et al., 2021)

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Additional information Peer review information : Nature Communications thanks Kazuei Igarashi, David Nielsen, and the other anonymous reviewer(s) for their contribution to the peer review of this work

To view a copy of this licence, visit About this article Cite this article Wu, Y., Xia, H., Ding, H

There exists a complex interaction between the CNS and bone, with one key aspect being the neuroregulation of bone metabolism

The presence of HOCl can also affect the phosphorylation state of protein kinase C leading to insulin resistance, however, this signaling is mediated via peroxynitrite [340]