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A.OBrienJ.BlackS.ChenC.DeCarliC.ErkinjunttiT.et al (2017)

87 Aspartate in cancer TP53 is a gene with the highest mutation frequency in human cancer

Studies have shown that the TGF-1 signaling pathway is a major player in tissue fibrosis, including IPF (47), and this signaling pathway involves several critical phosphorylation events

The results are consistently positive and the mechanistic data is compelling, but as of 2026 there are no completed Phase 3 human randomized controlled trials

Sun et al., 2016b

However, several drugs, including teprotumumab and BIIB-022, which target IGF-1R, have not shown good therapeutic effects in clinical trials, possibly due to the lack of reliable IGF-1R inhibition biomarkers