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Description

Pathologically, -Syn is subjected to a conformational change from -helical state to -sheet-rich oligomers and fibrils capable of aggregation due to mutations in its encoding gene SNCA, altering SNCA gene transcription and mRNA stability or processing (Nalls et al., 2019

The risks and benefits of invasive testing and procedures must be reviewed carefully in patients with all forms of EDS because bleeding complications, inadequate response to regional and local anesthesia, and iatrogenic injury are common

All of the animal experimentation work of this study was made at the Firat University Experimental Animals Research Institute (FUDAM), meeting date November 27, 2019, protocol number 2019-141, meeting number 2019-22, decision number: 222