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The activation of these proteins promotes apoptosis by facilitating the release of cytochrome c from mitochondria and inhibiting the activity of anti-apoptotic proteins such as Bcl-2 (Aroor and Shukla 2004)

The identified genes were not limited to those encoding metabolic enzymes, also genes encoding transporters and genes involved in cofactor synthesis were discovered

An Inveon small-animal PET scanner (Siemens, Erlangen, Germany) was used to acquire whole-body PET images at predetermined time points after injection

In vivo, LA can be reduced to dihydro LA (DH-LA) by dihydrolipoamide dehydrogenase [28]

then LOO + LH LOOH + L

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