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1,911 View 87 Download Efficacy and safety of mirikizumab in maintenance therapy for ulcerative colitis in difficult-to-treat inflammatory bowel disease: a single-center retrospective study in Japan Ichiro Mizushima, Yusuke Yoshimatsu, Hiroki Kiyohara, Shinya Sugimoto, Tomohisa Sujino, Kaoru Takabayashi, Yohei Mikami, Takanori Kanai Received August 13, 2025 Accepted November 19, 2025 Published online February 11, 2026 DOI: [Epub ahead of print] Abstract PDFSupplementary MaterialPubReaderePub Background/Aims Randomized controlled trials have confirmed the efficacy and safety of mirikizumab, an anti-interleukin-23p19 monoclonal antibody, for moderate-to-severe active ulcerative colitis (UC)

In the absence of clinical pathological or histopathological effects, the NOAEL for systemic toxicity was 1000 mg/kg bw per day, the highest dose tested (Goldenthal, 1991)

In various models built for injury and disease, HGF promotes cell survival and tissue regeneration, and improves chronic inflammation and fibrosis (Michalopoulos and Khan, 2005

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The same fragmentation pattern was also observed for the purified peptide conjugates (see for example Supplementary Fig