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For more information on PMTAs, the FDA prepared a Guidance for Industry called the Premarket Tobacco Product Applications for Electronic Delivery Systems (ENDS) and issued a final rule on Premarket Tobacco Product Applications and Recordkeeping Requirements in October of 2021

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Cells were plated in 24- or 6-well plates (EM), grown to confluence and placed overnight in BEBM containing transferrin, insulin, gentamicin and amphotericin B (Sigma-Aldrich)

Product B: Declared content: 200 mg/1 g, pouch weight: 0.5 g