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We recently found that systemic administration of GHSR antagonists, including the prototypical GHSR antagonist JMV2959 and the novel GHSR inverse agonist/antagonist PF-5190457 reduced alcohol intake in a Drinking-in-the-Dark (DID) mouse model of binge-like alcohol drinking [26]

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Research indicates that the elevation of endogenous GH may assist with the maintenance of healthy visceral adipose tissue levels in research models by activating hormone-sensitive lipase (HSL) and promoting lipid mobilization

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(2018) Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors, Oncol