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If you have absorption problems whether from digestive conditions, medications, or pernicious anemia oral supplements won't work effectively no matter how high the dose

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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

This is especially true if someone has already been diagnosed with vitamin B12 deficiency, which is most likely to affect vegetarians/vegans, older adults and people with malabsorption issues due to underlying health conditions