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Substance-use disorder: A diagnostic term in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) referring to recurrent use of alcohol or other drugs that causes clinically and functionally significant impairment, such as health problems, disability, and failure to meet major responsibilities at work, school, or home

Where nic salt e-liquid is different is through the addition of benzoic acid, which enables the nicotine content, even at higher levels, to be vaped with a much smoother hit, and at relatively low temperatures, ie without needing to adjust the temperature, hence the suitability to non-variable/non-adjustable devices such as pod systems and AIO kits

106 Daily use of e-cigarettes was not reportable among female smokers (Figure 11.15), but no significant difference was observed between male and female smokers (potentially due to small sample size)

Yang F, Pedersen NL, Ye W, Liu Z, Norberg M, Forsgren L, et al

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