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Cigarette smoking is the leading cause of preventable disease and death in the United States, according to the CDC

In the ESCAPE (Cohort Studies in Europe for Air Pollution Effects) study ( N = 100,166 from different cohorts) a substantial 13% relative rise in nonfatal acute coronary events was found, with a 5 g/m 3 increase in long-term PM 2.5 exposure (105)

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More recent research has continued to build on these findings, with studies examining not just traditional cigarettes but also smokeless tobacco and e-cigarettes, all of which introduce nicotine into the oral environment

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