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Palinski W, Horkko S, Miller E, Steinbrecher UP, Powell HC, Curtiss LK, et al

Defects in OCTN2 causes primary systemic carnitine deficiency presenting with cardiomyopathy and often myopathy and/or hepatic encephalopathy in early childhood, and is a treatable condition

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Examples Example 1: primary monocyte and macrophage system reappears biological properties of monocytes and macrophages in vivo Human macrophages exist along a spectrum of differentiation from pro-inflammatory (M1-like, also referred to herein as type 1) to pro-tumorigenic/anti-inflammatory (M2-like, also referred to herein as type 2) (see, e.g., Biswas et al (2010) nat

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