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10.3389/fgene.2023.1272446 256 SargentD.AmthorJ

withdraw and reposition

Similarly, glycine is a primary donor of single-carbon units to maintain 1-carbon cycle 14 , a key metabolic process that occurs mainly in the liver and regulates various methylation, redox, and biosynthetic reactions 15

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549 In pancreatic cancer, a 12-gene prognostic model based on nuclear-mitochondrial genes (NMGs) not only predicts immune microenvironment characteristics but also provides molecular guidance for personalized therapeutic strategies

This heterogeneity makes it difficult to define the state of T-cell exhaustion using a single indicator or feature, posing challenges for accurately assessing T-cell functional status and predicting immunotherapy outcomes (57)