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Allergic reactions to NAD+ are extremely rare, but as with any injectable substance, there is a remote possibility of hypersensitivity

Oxidative stress plays a pivotal role in podocyte injury, proteinuria, segmental glomerulosclerosis, and tubulointerstitial fibrosis by activating specific pathways and interacting with the TGF-/Smad signaling pathway to drive renal fibrosis [33]

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Thioredoxins are small redox proteins which act as antioxidants by reducing other proteins via cysteine thiol-disulphide exchange reactions and themselves are reduced by thioredoxin reductase