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Contraindicated in patients with active peptic ulcer, GI bleeding, or recent surgery with high bleeding risk

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There is no therapeutic procedure so far to ensure accurate axon-to-axon or endoneurium-to-endoneurium reconnection, and mismatch is unavoidable after nerve anastomosis via epineurial or perineurial suturing, no matter whether direct end-to-end suturing or nerve autografting is executed

They circulate, bind to a specific receptor, and deliver one instruction: repair this, release that, slow down, speed up