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As stigma is experienced by patients across this continuum of smoking exposures, the salience of this ethical debate is relevant for current, former, and never smokersall those suffering from illnesses associated with smoking

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exposure to nicotine during adolescence can cause addiction and can harm the developing adolescent brain. Nicotine harms parts of the brain that control attention, learning, mood, and impulse control. Nicotine also changes the way synapses connections between brain cells are formed

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Further, most of the small number of human studies that show beneficial effects of nicotine on attention, impulsivity, and ADHD symptoms in nonsmokers had small sample sizes and produced effects of relatively small magnitude