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and Blocking autoantibodies against FRs have been found in the blood of patients with cerebral folate deficiency (CFD)

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Also, MhTyrA is a monofunctional enzyme, while some archaea, fungi, and -proteobacteria orthologs in clade II are bifunctional and have a chorismate mutase enzyme domain (Hudson et al., 2017)

These efforts have successfully identified numerous lactylation modification sites and elucidated their roles in the development of various diseases

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however, little is known about the mechanisms by which the acquired resistance arises