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Sperm flagellar abnormalities, such as hypertrophy and hyperplasia of the fibrous sheath, axonemal disruption, defects of the inner microtubular dynein arms, and abnormal or absent midpiece have all be associated with zinc deficiency.[20] Studies have shown a beneficial effect for zinc supplementation in patients with iOAT demonstrated by improvements in sperm concentration, progressive motility, sperm integrity, and pregnancy rates.[29,65] Omu et al

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Furthermore, no well-dened genetic variants were found in GSH, except for single nucleotide polymorphisms (SNPs) in GS, namely rs7265992, rs6060124, rs7260770, rs4911455, rs6088662, and in GPX5, namely rs377514

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The absence of energy prevents the pumps from removing glutamate from the synapse