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Clinical trials of inhibitors like Setanaxib have reported good tolerability, but concerns remain about long-term impacts on immune function, as reduced reactive oxygen species might weaken pathogen clearance, potentially increasing infection risks

Aug 2012;71(8):1267-1272

Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study