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doi: 10.1038/s41577-023-00837-1 59 ColonnaM.ButovskyO

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Large genomic amplifications induced by c-Myc overexpression are attributed to replicative stress caused by unscheduled DNA replication and increased oxidative stress leading to DNA breaks (Kuzyk and Mai, 2014)

Very recently, 7-DHC has also been shown to have superior reactivity toward peroxyl radicals and effectively protect phospholipids from peroxidation and ferroptotic cell death in cancer cells 14

(III) Early efforts characterizing ferroptosis have predominately focused on examining characteristic hallmarks, while less is known about the exact mechanisms that drive the phenotype [83]

Cataldo AM, McPhie DL, Lange NT, Punzell S, Elmiligy S, Ye NZ, et al