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Recently, its deficiency has been linked to an increased risk of thyroid autoimmunity since it impairs lymphocyte proliferation and antioxidant defenses

International consortia like the Organization for Economic Co-operation and Development (OECD) are also exploring the standardization of these systems for specific toxicological endpoints (224)

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Variable patterns of mRNA transcriptions have also been found which lead to a variable protein phenotype resulting in differences in behaviour and response to drugs and growth factors [71]

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