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Peripheral supplementation of MANF has shown potential to reduce infarct volume and neuroinflammation in ischemic stroke models, highlighting its therapeutic promise for other neurological diseases [149]

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Alternatively, inhibition of PDGFR might induce the expression of angiopoietin-like 4 (Angptl4), which augments angiogenesis 36

Reducing the dose and administering it with meals will minimize these effects in the sensitive patient