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The authors used flow cytometry and immunohistochemistry to demonstrate that macrophages that entered the kidneys (F4/80+ or CD68+) largely created mincle

Interestingly, occludin knockout mice had morphologically intact tight junctions but displayed complex histological phenotypes, with chronic inflammation and a defective epithelial barrier, which implicated that its crucial role was in tight junction stability rather than tight junction assembly

Cancers (Basel) (2018) 10(8):248

You et al

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Recent studies have revealed that calpain-2 conditional knockout mice are protected against the pathological consequences of repeated mild TBI and that genetic deletion or pharmaceutical inhibition of calpain-2 prevented alterations in the subcellular localization of TDP-43