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Dose-adjusted DOACs have been primarily examined in randomized controlled trials (RCTs) to prevent stroke in specific subgroups of patients with AFib, such as patients with advanced age, low body weight, renal dysfunction, and/or drug interactions

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doi: 10.1016/j.clim.2024.110181 226 CirilloLInnocentiSBecherucciF

Casecontrol studies have shown higher salivary and systemic markers of periodontitis and increased detection of periodontal pathogens in stroke patients compared with controls, consistent with advanced periodontal disease and elevated systemic inflammatory burden (96)

Excess levels of superoxide can dismutate either spontaneously to H 2 O 2 or following catalysis by superoxide dismutase (SOD)