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28 Co-occurring conditions like anxiety, depression, stress, and sleep disorders can be contributors, while disturbances that are difficult to diagnose, such as dysregulated stress reactivity, neurotransmitter imbalance, inflammation, mitochondrial dysfunction, free radical damage, hormonal imbalance, and metabolic disturbance, as well as crosstalk between these factors, may also play a role

Vitamin B-12 is required for many internal activities, including nerve function and the creation of DNA and red blood cells

If your chronic fatigue seems to get better only with adenosyl B12 (and not with methyl B12), its possible that you have some rare condition preventing your body from the inter-conversion

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Anaemia B12 and folate deficiency: NICE Clinical Knowledge Summaries

Il est recommand de vrifier l'hmatocrite, le nombre de rticulocytes, la vitamine B12, les folates et les niveaux de fer avant le dbut du traitement